SUPER League champions Zesco United have been drawn against Niger side AS Sonidep while Green Buffaloes will play El Merreikh Juba of South Sudan in the CAF Champions League and Confederation Cup respectively.
Debutants Green Eagles have been drawn against eSwatini outfit Young Buffaloes while Nkana face Mozambique side US Songo in other continental ties.
First leg fixtures will be staged on November 27-28 while return leg matches will be played on December 4-5.
Green Eagles will be at home in the first leg on November 27, and should they negotiate their way past the preliminaries, will meet Congo Brazzaville outfit Diable Noir.
CAF has revised the calendar of their competitions to be aligned with the FIFA calendar.
Nkana and Zesco United who are campaigning in the Champions League will be away in their first fixtures while Green Buffaloes and Green Eagles will be at home for their first legs of the Confederation Cup.